Ibrutinib dimer(Synonyms: 依鲁替尼二聚体)

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Ibrutinib dimer (Synonyms: 依鲁替尼二聚体)

Ibrutinib dimer 是 Ibrutinib 的二聚体。Ibrutinib dimer 是 Ibrutinib 的一种杂质。Ibrutinib 是一种不可逆的选择性 Btk 抑制剂，IC₅₀ 为 0.5 nM。

Ibrutinib dimer Chemical Structure

CAS No. : 2031255-23-7

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生物活性	Ibrutinib dimer is a Dimer of Ibrutinib. Ibrutinib dimer is an impurity of Ibrutinib^[1]. Ibrutinib is a selective, irreversible Btk inhibitor with an IC₅₀ of 0.5 nM^[2].
分子量	880.99
Formula	C₅₀H₄₈N₁₂O₄
CAS 号	2031255-23-7
中文名称	依鲁替尼二聚体
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Somana Siva Prasad, et al. A QUALITY BY DESIGN APPROACH FOR DEVELOPMENT OF SIMPLE AND ROBUST REVERSED PHASE STABILITY INDICATING HPLC METHOD FOR ESTIMATION OF IBRUTINIB AND ITS IMPURITIES. [2]. Honigberg LA, et al. The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy. Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):13075-80.

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