Ezetimibe-d4 diacetate(Synonyms: 依泽替米贝 双乙酸酯 d4)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Ezetimibe-d4 diacetate (Synonyms: 依泽替米贝 双乙酸酯 d4)

Ezetimibe-d4 diacetate 是 Ezetimibe 的氘代物。Ezetimibe (SCH 58235) 是有效的胆固醇吸收 (cholesterol-absorption) 抑制剂。Ezetimibe 是一种 NPC1L1 抑制剂，是有效的 Nrf2 激活剂。

Ezetimibe-d4 diacetate(Synonyms: 依泽替米贝 双乙酸酯 d4)

Ezetimibe-d4 diacetate Chemical Structure

CAS No. : 1217861-13-6

规格 是否有货
1 mg Check price and availability
10 mg Check price and availability

* Please select Quantity before adding items.

生物活性

Ezetimibe-d4 diacetate is the deuterium labeled Ezetimibe. Ezetimibe (SCH 58235) is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator[1][2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

497.52

Formula

C28H21D4F2NO5
CAS 号

1217861-13-6
中文名称

依泽替米贝 双乙酸酯 d4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Lee DH, et al. Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis. Free Radic Biol Med. 2016 Sep 12;99:520-532.

    [3]. Chang E, et al. Ezetimibe improves hepatic steatosis in relation to autophagy in obese and diabetic rats. World J Gastroenterol. 2015 Jul 7;21(25):7754-63.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务