Candesartan-d5 Methyl Ester(Synonyms: 坎地沙坦甲酯 d5)

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Candesartan-d5 Methyl Ester (Synonyms: 坎地沙坦甲酯 d5)

Candesartan-d5 Methyl Ester 是 Candesartan 的氘代物。Candesartan是血管紧张素II受体拮抗剂，IC50为0.26 nM。

Candesartan-d5 Methyl Ester(Synonyms: 坎地沙坦甲酯 d5)

Candesartan-d5 Methyl Ester Chemical Structure

CAS No. : 1216502-48-5

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生物活性

Candesartan-d5 Methyl Ester is the deuterium labeled Candesartan. Candesartan is an angiotensin II receptor antagonist with IC50 of 0.26 nM.

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

459.51

Formula

C25H17D5N6O3
CAS 号

1216502-48-5
中文名称

坎地沙坦甲酯 d5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Pfeffer MA, et al. Effects of candesartan on mortality and morbidity in patients with chronic heart failure: the CHARM-Overall programme. Lancet. 2003 Sep 6;362(9386):759-66.

    [3]. Nishimura Y, et al. Chronic peripheral administration of the angiotensin II AT(1) receptor antagonist candesartan blocks brain AT(1) receptors. Brain Res. 2000 Jul 14;871(1):29-38.

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