2-Hydroxyestrone-d4(Synonyms: Catecholestrone-d4)

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2-Hydroxyestrone-d4 (Synonyms: Catecholestrone-d4)

2-Hydroxyestrone-d4 (Catecholestrone-d4) 是 2-Hydroxyestrone 的氘代物。2-Hydroxyestrone (Catecholestrone) 是一种特异性受体介导的抗雌激素剂。2-Hydroxyestrone 具有抗癌作用。

2-Hydroxyestrone-d4(Synonyms: Catecholestrone-d4)

2-Hydroxyestrone-d4 Chemical Structure

CAS No. : 81586-97-2

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生物活性

2-Hydroxyestrone-d4 (Catecholestrone-d4) is the deuterium labeled 2-Hydroxyestrone. 2-Hydroxyestrone (Catecholestrone) is a specific receptor-mediated antiestrogenic agent. 2-Hydroxyestrone is anticarcinogenic[1][2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

290.39

Formula

C18H18D4O3
CAS 号

81586-97-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. H L Bradlow, et al. 2-Hydroxyestrone: the ‘good’ estrogen. J Endocrinol. 1996 Sep;150 Suppl:S259-65.

    [3]. J Schneider, et al. Antiestrogen action of 2-Hydroxyestrone on MCF-7 human breast cancer cells. J Biol Chem. 1984 Apr 25;259(8):4840-5.

    [4]. M Nakagomi, et al. Quantitation of catechol estrogens and their N-acetylcysteine conjugates in urine of rats and hamsters. Chem Res Toxicol. 2000 Dec;13(12):1208-13.

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