Acetylcholine-d4 chloride(Synonyms: ACh-d4 chloride)

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Acetylcholine-d4 chloride (Synonyms: ACh-d4 chloride)

Acetylcholine-d9 (ACh-d9) chloride 是 Acetylcholine chloride 的氘代物。Acetylcholine chloride (ACh chloride) 是一种神经递质，是一种有效的胆碱能 (cholinergic) 激动剂。Acetylcholine chloride 是通过刺激烟碱乙酰胆碱受体 (nAChRs) 调节多巴胺能 (DAergic) 神经元活性。Acetylcholine chloride 在体外抑制 p53 突变肽的聚集。

Acetylcholine-d4 chloride(Synonyms: ACh-d4 chloride)

Acetylcholine-d4 chloride Chemical Structure

CAS No. : 344298-94-8

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生物活性

Acetylcholine-d9 (ACh-d9) chloride is the deuterium labeled Acetylcholine chloride. Acetylcholine chloride (ACh chloride), a neurotransmitter, is a potent cholinergic agonist. Acetylcholine chloride is a modulator of the activity of dopaminergic (DAergic) neurons through the stimulation of nicotinic acetylcholine receptors (nAChRs)[1][2]. Acetylcholine chloride inhibits p53 mutant peptide aggregation in vitro[5].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

185.69

Formula

C7H12D4ClNO2
CAS 号

344298-94-8
中文名称

氯化乙酰胆碱 d4 (氯化物)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Prashant Tiwari, et al. Basic and modern concepts on cholinergic receptor: A review. Asian Pac J Trop Dis. 2013 Oct;3(5): 413-420.

    [3]. A Young, et al. Diarrhoea of famine and malnutrition–investigations using a rat model. 2–Ileal hypersecretion induced by starvation. Gut. 1990 Feb;31(2):162-9.

    [4]. Xia Lei, et al. Effects of acetylcholine chloride on intracellular calcium concentration of cultured sweat gland epithelial cells. Arch Dermatol Res. 2008 Aug;300(7):335-41.

    [5]. P F Zabrodskii, et al. Effect of acetylcholine on mortality of mice from sepsis and proinflammatory cytokine production. Bull Exp Biol Med. 2011 Jan;150(3):340-2.

    [6]. Zhaolin Chen, et al. Inhibition of p53 Mutant Peptide Aggregation In Vitro by Cationic Osmolyte Acetylcholine Chloride. Protein Pept Lett. 2017;24(4):353-357.

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