IWP-3

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

IWP-3 

IWP-3 是有效的 Wnt 产生抑制剂，IC50 为 40 nM。IWP-3 抑制 Porcupine (Porcn) 功能，从而阻断 Wnt 蛋白的棕榈酰化。IWP-3 仅适度抑制 CK1γ3 和 CK1ε，不抑制 CK1α。

IWP-3

IWP-3 Chemical Structure

CAS No. : 687561-60-0

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生物活性

IWP-3 is an potent inhibitor of Wnt production with an IC50 of 40 nM. IWP-3 inhibits Porcupine (Porcn) function thereby blocking palmitoylation of Wnt proteins. IWP-3 inhibits CK1γ3 and CK1ε only moderately and does not inhibit CK1α[1][2].

IC50 & Target[1]

Wnt

40 nM (IC50)

分子量

484.59

Formula

C22H17FN4O2S3
CAS 号

687561-60-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Baozhi Chen, et al. Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nat Chem Biol. 2009 Feb;5(2):100-7.

    [2]. Balbina García-Reyes, et al. Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε. J Med Chem. 2018 May 10;61(9):4087-4102.

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