Adenosine receptor antagonist 2

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Adenosine receptor antagonist 2 

Adenosine receptor antagonist 2 是一种口服有效的 A2a/A2b 腺苷受体拮抗剂，IC50 分别为 1 nM 和 3 nM。Adenosine receptor antagonist 2 具有抗肿瘤活性。

Adenosine receptor antagonist 2

Adenosine receptor antagonist 2 Chemical Structure

CAS No. : 2703054-47-9

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生物活性

Adenosine receptor antagonist 2 is an orally active A2a/A2b adenosine receptor antagonist with IC50s of 1 nM and 3 nM, respectively. Adenosine receptor antagonist 2 has anti-tumor activity[1].

IC50 & Target[1]

A2a adenosine receptor

1 nM (IC50)

A2b adenosine receptor

3 nM (IC50)

体内研究
(In Vivo)

Adenosine receptor antagonist 2 (compound L-1; po; 10, 30, 100 mg/kg; twice a day for 22 days) inhibits tumor growth in female C57BL / 6mice mice with MC38(#22)-hpd-L1 cells[1].
Adenosine receptor antagonist 2 (iv; 2 mg/kg) has a CLz of 14.7 mL/min·kg and an AUC of 2252 h·ng/mL. Adenosine receptor antagonist 2 (po; 10 mg/kg) has a Cmax of 8730 ng/mL in adult male ICR mice (weight 25-40g)[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

444.46

Formula

C23H21FN8O
CAS 号

2703054-47-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Lifeng Liu, et al. Substituted pyrimidine or Pyridylamine derivatives, their compositions and pharmaceutical uses. WO2021185256A1.

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