Izilendustat hydrochloride

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Izilendustat hydrochloride 

Izilendustat (hydrochloride) 是一种有效的脯氨酰羟化酶 (prolyl hydroxylase) 抑制剂，可稳定缺氧诱导因子-1 α (HIF-1α) 和缺氧诱导因子-2 (HIF-2)。Izilendustat (hydrochloride) 具有研究 HIF-1α 相关疾病的潜力，包括外周血管疾病（PVD）、冠状动脉疾病（CAD）、心力衰竭、缺血、贫血、结肠炎和其他炎症性肠病 (信息提取自专利 WO2011057115A1/WO2011057112A1/WO2011057121A1)。

Izilendustat hydrochloride

Izilendustat hydrochloride Chemical Structure

CAS No. : 1303513-80-5

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Izilendustat hydrochloride 的其他形式现货产品:

Izilendustat

生物活性

Izilendustat (hydrochloride) is a potent inhibitor of prolyl hydroxylase which stabilizes hypoxia inducible factor- 1 alpha (HIF- lα), as well as hypoxia inducible factor-2 (HIF-2). Izilendustat (hydrochloride) has the potential for the research of HIF- lα related diseases including Peripheral Vascular Disease (PVD), Coronary Artery Disease (CAD), heart failure, ischemia, anemia, colitis, and other inflammatory bowel diseases (extracted from patent WO2011057115A1/WO2011057112A1/WO2011057121A1)[1][2][3].

IC50 & Target

prolyl hydroxylase[1]
分子量

470.39

Formula

C22H29Cl2N3O4
CAS 号

1303513-80-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Joseph H, et al. Prolyl hydroxylase inhibitors. Patent WO2011057115A1.

    [2]. Robert Shalwitz, et al. Methods for increasing the stabilization of hypoxia inducible factor-1 alpha. Patent WO2011057112A1.

    [3]. Joseph H, et al. Compositions and methods for treating colitis. Patent WO2011057121A1.

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