上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。
Envonalkib
Envonalkib 是一种有效和具有口服活性的 ALK 抑制剂，抑制 WT 和突变的 L1196M 和 G1269S-ALK 的 IC50 值分别为 1.96 nM，35.1 nM 和 61.3 nM。Envonalkib 可用于非小细胞肺癌的研究。
Envonalkib Chemical Structure
CAS No. : 1621519-26-3
| 规格 | 是否有货 | ||
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| 100 mg | 询价 | ||
| 250 mg | 询价 | ||
| 500 mg | 询价 |
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| 生物活性 |
Envonalkib is a potent and orally active inhibitor of ALK, with IC50s of 1.96 nM, 35.1 nM, and 61.3 nM for WT and mutated L1196M and G1269S-ALK. Envonalkib can be used for the research of non-small cell lung cancer[1]. |
IC50 & Target |
IC50: 1.96 nM (WT-ALK), 35.1 nM (mutated L1196M-ALK), 61.3 nM (mutated G1269S-ALK)[1] |
|---|---|
| 体内研究 (In Vivo) |
Envonalkib (formula I) (12.5-25 mg/kg; p.o. once daily for 14 days) inhibits the growth of human non-small cell lung cancer NCI-H2228 nude mice xenografts[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
| 分子量 |
506.40 |
| Formula |
C24H26Cl2FN5O2 |
| CAS 号 |
1621519-26-3 |
| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
| 储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
| 参考文献 |
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