KRAS G12C inhibitor 18

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KRAS G12C inhibitor 18 

KRAS G12C inhibitor 18 是一种口服有效的 KRAS G12C 抑制剂。KRAS G12C inhibitor 18 具有抗肿瘤活。

KRAS G12C inhibitor 18

KRAS G12C inhibitor 18 Chemical Structure

CAS No. : 2649788-45-2

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生物活性

KRAS G12C inhibitor 18 is a potent and orally active KRAS G12C inhibitor. Anti-tumor activities[1].

IC50 & Target[1]

KRas G12C

 

体外研究
(In Vitro)

KRAS G12C inhibitor 18 (compound 34) inhibits the growth of many KRas G12C mutant tumor cell lines (such as H358, SW1436, MiaPaca-2 cells, etc.)[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

KRAS G12C inhibitor 18 exhibits a dose dependent inhibiton of pERK and active KRas after a single dose treatment from 12.5 to 100 mg/kg at 8 hours[1].
KRAS G12C inhibitor 18 (30 mg/kg; p.o.; twice daily) exhibits anti-tumor growth activity in lung cancer H358 xenograft mouse model[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

510.97

Formula

C25H20ClFN4O3S
CAS 号

2649788-45-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Serge Louis Boulet, et al. Kras g12c inhibitors. WO2021118877A1.

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