Ipatasertib-NH2 dihydrochloride(Synonyms: GDC-0068-NH2 dihydrochloride; RG7440-NH2 dihydrochloride)

发表于由

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Ipatasertib-NH2 dihydrochloride (Synonyms: GDC-0068-NH2 dihydrochloride; RG7440-NH2 dihydrochloride)

Ipatasertib-NH2 dihydrochloride 是 PROTAC (INY-03-041) 靶蛋白 AKT 的配体。INY-03-041 由 Ipatasertib-NH2、一个十烃连接体和一个用于 E3 泛素连接酶的 CRBN 配体 Lenalidomide 组成。

Ipatasertib-NH2 dihydrochloride(Synonyms: GDC-0068-NH2 dihydrochloride; RG7440-NH2 dihydrochloride)

Ipatasertib-NH2 dihydrochloride Chemical Structure

CAS No. : 1001264-73-8

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Ipatasertib-NH2 dihydrochloride 的其他形式现货产品:

Ipatasertib-NH2

生物活性

Ipatasertib-NH2 dihydrochloride is a ligand for target protein AKT for PROTAC (INY-03-041). INY-03-041 is composed of Ipatasertib-NH2, a ten-hydrocarbon linker, and a CRBN ligand Lenalidomide for E3 ubiquitin ligase[1].

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

488.84

Formula

C21H28Cl3N5O2
CAS 号

1001264-73-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. You I, et al. Discovery of an AKT Degrader with Prolonged Inhibition of Downstream Signaling. Cell Chem Biol. 2020 Jan 16;27(1):66-73.e7.

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