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Venadaparib hydrochloride (Synonyms: IDX-1197 hydrochloride)
Venadaparib (IDX-1197) hydrochloride 是一种有效的选择性 PARP 抑制剂，具有抗癌活性。Venadaparib hydrochloride 可用于实体瘤研究。
Venadaparib hydrochloride Chemical Structure
CAS No. : 1681020-60-9
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| 生物活性 |
Venadaparib (IDX-1197) hydrochloride is a potent and selective PARP inhibitor with anticancer activities. Venadaparib hydrochloride can be used for solid tumors research[1][2]. |
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| 体外研究 (In Vitro) |
Venadaparib (example 143; 6-10 days) shows potent growth inhibition of MDA-MB-436 cells and Capan-1 pancreatic cancer cells with IC50 values of ≤5nM and 50nM Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
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| 体内研究 (In Vivo) |
In the germline BRCA1-mutated ovarian cancer PDX model, oral administration of Venadaparib (IDX-1197) exhibits significant PAR inhibition (>90%) in tumor tissues until 24 hr post dose. Venadaparib also dose-dependently led to potent tumor growth inhibition compared to Olaparib treatment group[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
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| 分子量 |
442.91 |
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| Formula |
C23H24ClFN4O2 |
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| CAS 号 |
1681020-60-9 |
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
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| 参考文献 |
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