Thalidomide-NH-C2-PEG3-OH

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Thalidomide-NH-C2-PEG3-OH 

Thalidomide-NH-C2-PEG3-OH 是一种 E3 连接酶配体-linker 偶联物 (E3 ligase ligand-linker conjugate)，包含基于 Thalidomide 的 cereblon 配体和 1 个 linker。用于合成 PROTAC BCL-XL 降解剂 XZ739。

Thalidomide-NH-C2-PEG3-OH

Thalidomide-NH-C2-PEG3-OH Chemical Structure

CAS No. : 2140807-23-2

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生物活性

Thalidomide-NH-C2-PEG3-OH is an E3 ligase ligand-linker conjugate that incorporates Thalidomide based cereblon ligand and a linker used for PROTAC BCL-XL degrader XZ739[1].

IC50 & Target

Cereblon

 

体外研究
(In Vitro)

XZ739, a CRBN-dependent PROTAC BCL-XL degrader with a DC50 value of 2.5 nM in MOLT-4 cells after 16 h treatment. XZ739 also induces cell death through caspase-mediated apoptosis[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

449.45

Formula

C21H27N3O8
CAS 号

2140807-23-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Xuan Zhang,et al. Discovery of PROTAC BCL-X L Degraders as Potent Anticancer Agents With Low On-Target Platelet Toxicity. Eur J Med Chem. 2020 Apr 15;192:112186.

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