Sodium Camptothecin(Synonyms: 喜树碱钠盐)

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Sodium Camptothecin (Synonyms: 喜树碱钠盐)

Sodium Camptothecin 是一种具有抗肿瘤活性的植物生物碱。Sodium Camptothecin 是一种可逆的 RNA 合成 (RNA synthesis) 抑制剂。Sodium Camptothecin 是一种有效的腺病毒复制抑制剂。Sodium Camptothecin 能抑制 DNA 合成 (DNA synthesis)，并引起细胞内预形成的病毒 DNA 断裂。

Sodium Camptothecin(Synonyms: 喜树碱钠盐)

Sodium Camptothecin Chemical Structure

CAS No. : 25387-67-1

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生物活性

Sodium Camptothecin is a plant alkaloid, with antitumor activity. Sodium Camptothecin is a reversible inhibitor of RNA synthesis. Sodium Camptothecin is an effective inhibitor of adenovirus replication. Sodium Camptothecin inhibits DNA synthesis and causes breaks in intracellular preformed viral DNA[1][2].

体外研究
(In Vitro)

Sodium Camptothecin (5 μM; 10 min) causes a severe inhibition of heterogeneously sedimenting nuclear RNA (HnRNA) synthesis[1].
Sodium Camptothecin also blocks a specific step in the processing of ribosomal precursor RNA, allowing the conversion of 45S RNA to 32S RNA, but inhibiting the conversion of 32S RNA to 28S RNA [1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

388.35

Formula

C20H17N2NaO5
CAS 号

25387-67-1
中文名称

喜树碱钠盐
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. R S Wu, et al. Ribosome formation is blocked by camptothecin, a reversible inhibitor of RNA synthesis. Proc Natl Acad Sci U S A. 1971 Dec;68(12):3009-14.

    [2]. M S Horwitz, et al. Camptothecin: mechanism of inhibition of adenovirus formation. Virology. 1972 Jun;48(3):690-8

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