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Pomalidomide-amido-PEG3-C2-NH2 (Synonyms: Cereblon Ligand-Linker Conjugates 22; E3 ligase Ligand-Linker Conjugates 55)
Pomalidomide-amido-PEG3-C2-NH2 (Cereblon Ligand-Linker Conjugates 22) 是一种合成的 E3 连接酶配体-linker 偶联物，包含基于 Pomalidomide 的 cereblon 配体和 3 个单元 PEG 的 linker。
Pomalidomide-amido-PEG3-C2-NH2 Chemical Structure
CAS No. : 2328070-52-4
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| 生物活性 |
Pomalidomide-amido-PEG3-C2-NH2 (Cereblon Ligand-Linker Conjugates 22) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology[1]. |
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| 体外研究 (In Vitro) |
Pomalidomide-amido-PEG3-C2-NH2 (Compound 5b) can be used to synthesize BI-3663. BI-3663 (cereblon-based) degrades focal adhesion tyrosine kinase (PTK2) with a median DC50 of 30 nM to >80% across a panel of 11 human hepatocellular carcinoma (HCC) cell lines[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
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| 分子量 |
476.48 |
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| Formula |
C22H28N4O8 |
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| CAS 号 |
2328070-52-4 |
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
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