BAY-6035

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

BAY-6035 

BAY-6035 是一种有效的，选择性，底物竞争性 SMYD3 抑制剂。 BAY-6035 抑制 MEKK2 的甲基化，IC50 值为 88 nM。

BAY-6035

BAY-6035 Chemical Structure

CAS No. : 2247890-13-5

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生物活性

BAY-6035 is a potent, selective and substrate-competitive inhibitor of SMYD3. BAY-6035 inhibits methylation of MEKK2 peptide with an IC50 of 88 nM[1].

IC50 & Target[1]

SMYD3

88 nM (IC50)

体外研究
(In Vitro)

BAY-6035 inhibits in vitro methylation of MEKK2 peptide with an IC50 of 88 nM and has more than 100-fold selectivity over other histone methyltransferases[1].
BAY-6035 inhibits the methylation of MEKK2 in cells with an IC50 of 70 nM[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

396.48

Formula

C22H28N4O3
CAS 号

2247890-13-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Edoardo F, et, al. Small-molecule inhibitors of lysine methyltransferases SMYD2 and SMYD3: current trends. Future Med Chem. 2019 Apr; 11(8): 901-921.

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