上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
EGFR-IN-1 hydrochloride
EGFR-IN-1 hydrochloride 是一种口服活性不可逆的突变型选择性 L858R/T790M EGFR 抑制剂。与野生型 EGFR 相比,EGFR-IN-1 hydrochloride 对 Gefitinib 耐药的 EGFR L858R/T790M 有 100 倍的抑制作用。EGFR-IN-1 hydrochloride 对 H1975 细胞和 HCC827 细胞具有较强的抗增殖活性。具有抗肿瘤活性。
EGFR-IN-1 hydrochloride Chemical Structure
CAS No. : 2227455-78-7
规格 | 是否有货 | ||
---|---|---|---|
100 mg | 询价 | ||
250 mg | 询价 | ||
500 mg | 询价 |
* Please select Quantity before adding items.
EGFR-IN-1 hydrochloride 的其他形式现货产品:
生物活性 |
EGFR-IN-1 hydrochloride is an orally active and irreversible L858R/T790M mutant selective EGFR inhibitor. EGFR-IN-1 hydrochloride potently inhibits Gefitinib-resistant EGFR L858R, T790M with 100-fold selectivity over wild-type EGFR. EGFR-IN-1 hydrochloride displays strong antiproliferative activity against the H1975 cells and the first line mutant HCC827 cells. Antitumor activity[1]. |
||||||||
---|---|---|---|---|---|---|---|---|---|
IC50 & Target[1] |
|
||||||||
体外研究 (In Vitro) |
EGFR-IN-1 hydrochloride (compound 24) (10 μM; 72 hours) displays strong antiproliferative activity against the H1975 and HCC827 cells with IC50s of 4 and 28 nM, respectively[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation Assay[1]
|
||||||||
体内研究 (In Vivo) |
EGFR-IN-1 hydrochloride (30 mg/kg; p.o.; daily for 2 weeks) displays significant tumor growth inhibition with no observed loss in body weight[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
|
||||||||
分子量 |
551.04 |
||||||||
Formula |
C28H31ClN6O4 |
||||||||
CAS 号 |
2227455-78-7 |
||||||||
运输条件 |
Room temperature in continental US; may vary elsewhere. |
||||||||
储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
||||||||
参考文献 |
|
所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务