hDDAH-1-IN-1 TFA

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

hDDAH-1-IN-1 TFA 

hDDAH-1-IN-1TFA (compound 8a) 是一种高效、选择性的非氨基酸 hDDAH-1 催化位点抑制剂，Ki 值为 18 μM。

hDDAH-1-IN-1 TFA

hDDAH-1-IN-1 TFA Chemical Structure

CAS No. : 1229238-70-3

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生物活性

hDDAH-1-IN-1 TFA (compound 8a) is a potent and selective non-amino acid catalytic site inhibitor of human dimethylarginine dimethylaminohydrolase-1 (hDDAH-1), with a Ki of 18 µM[1].

体外研究
(In Vitro)

hDDAH-1-IN-1 TFA potently inhibits hDDAH-1 (Ki = 18 µM) without significantly affecting NOSs and arginase[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

416.32

Formula

C12H22F6N4O5
CAS 号

1229238-70-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Lunk I, et al. Discovery of N-(4-Aminobutyl)-N’-(2-methoxyethyl)guanidine as the First Selective, Nonamino Acid, Catalytic Site Inhibitor of Human Dimethylarginine Dimethylaminohydrolase-1 (hDDAH-1). J Med Chem. 2019 Dec 31.

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