Tubulysin E(Synonyms: 微管蛋白抑制剂 E)

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Tubulysin E (Synonyms: 微管蛋白抑制剂 E)

Tubulysin E 是一种高度细胞毒性的肽，是从粘细菌 Archangium geophyra 和 Angiococcus disciformis 中分离的。 Tubulysin 在哺乳动物细胞中显示出极其有效的细胞毒活性，包括多药耐药细胞系，IC50 值在较低的纳摩尔范围内。 Tubulysin E 是一种具有细胞毒性活性微管溶素，抑制微管蛋白聚合并导致细胞周期停滞和凋亡。

Tubulysin E(Synonyms: 微管蛋白抑制剂 E)

Tubulysin E Chemical Structure

CAS No. : 309935-58-8

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生物活性

Tubulysin E is a highly cytotoxic peptide isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis. Tubulysin displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC50 values in the lower nanomolar range[1]. Tubulysin E is a cytotoxic activity tubulysin which inhibits tubulin polymerization and leads to cell cycle arrest and apoptosis[2].

分子量

814.04

Formula

C42H63N5O9S
CAS 号

309935-58-8
中文名称

微管蛋白抑制剂 E
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Kubicek K, et al. The tubulin-bound structure of the antimitotic drug tubulysin. Angew Chem Int Ed Engl. 2010 Jun 28;49(28):4809-12.

    [2]. Vlahov IR, et al. Acid mediated formation of an N-acyliminium ion from tubulysins: a new methodology for the synthesis of natural tubulysins and their analogs. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6778-81.

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