DC4SMe

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

DC4SMe 

DC4SMe 是 DNA 烷化剂 DC4 的磷酸盐前药，可用于合成抗体偶联药物 (ADC)。DC4SMe 对 Ramos，Namalwa 和 HL60/s 癌细胞的 IC50 值分别为 1.9 nM, 2.9 nM, 和 1.8 nM。DC4SMe 可用于靶向研究癌症。

DC4SMe

DC4SMe Chemical Structure

CAS No. : 615538-47-1

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

DC4SMe, a phosphate prodrug of cytotoxic DNA alkylator DC4, can be used in the synthesis of Antibody-drug Conjugate (ADC). DC4SMe exhibits IC50s of 1.9 nM, 2.9 nM, and 1.8 nM for Ramos, Namalwa, and HL60/s cancer cells, respectively. DC4SMe can be used for the targeted treatment of cancer[1].

IC50 & Target[1]

Duocarmycins

 

体外研究
(In Vitro)

The phosphate prodrug may be a suitable choice for ADCs of effector molecules that do not possess sufficient water solubility or stability[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

764.21

Formula

C35H31ClN5O7PS2
CAS 号

615538-47-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Zhao RY, et al. Synthesis and biological evaluation of antibody conjugates of phosphate prodrugs of cytotoxic DNA alkylators for the targeted treatment of cancer. J Med Chem. 2012 Jan 26;55(2):766-82.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务