DC41

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

DC41 

DC41是一种DC1衍生物。DC1，CC-1065 的简化类似物，靶向细胞毒性 DNA 烷基化酶的抗体偶联物，用于癌症的研究。

DC41

DC41 Chemical Structure

CAS No. : 1354787-69-1

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生物活性

DC41 is a DC1 derivative. DC1, a simplified analogue of CC-1065, is an antibody conjugate of cytotoxic DNA alkylators for the targeted treatment of cancer[1][2].

IC50 & Target

Duocarmycins

 

分子量

680.21

Formula

C37H34ClN5O4S
CAS 号

1354787-69-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Zhao RY, et al. Synthesis and biological evaluation of antibody conjugates of phosphate prodrugs of cytotoxic DNA alkylators for the targeted treatment of cancer. J Med Chem. 2012 Jan 26;55(2):766-82.

    [2]. Kovtun YV, et al. Antibody-drug conjugates designed to eradicate tumors with homogeneous and heterogeneous expression of the target antigen. Cancer Res. 2006 Mar 15;66(6):3214-21.

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