PAD2-IN-1

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

PAD2-IN-1 

PAD2-IN-1，一种基于苯并咪唑的衍生物，是一种有效的选择性蛋白精氨酸脱亚氨酶 2 (PAD2) 抑制剂。PAD2-IN-1 对 PAD2 的选择性优于 PAD4 (95 倍) 和 PAD3 (79 倍)。

PAD2-IN-1

PAD2-IN-1 Chemical Structure

CAS No. : 2095109-82-1

规格 价格 是否有货
5 mg ￥9500 询问价格 & 货期
10 mg ￥16500 询问价格 & 货期

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生物活性

PAD2-IN-1, a benzimidazole-based derivative, is a potent and selective protein arginine deiminase 2 (PAD2) inhibitor. PAD2-IN-1 shows superior selectivity for PAD2 over PAD4 (95-fold) and PAD3 (79-fold)[1].

IC50 & Target

Protein Arginine Deiminase 2 (PAD2)[1]
体外研究
(In Vitro)

In the target engagement assay, the EC 50 of PAD2-IN-1 (compound 32a) is 8.3 μM in HEK293T/PAD2 cells, the enhanced potency of PAD2-IN-1 overcomes its relatively poor ability to enter cells[1].
PAD2-IN-1 (compound 32a; 1-25 μM) treatment strongly inhibits histone H3 citrullination with an EC 50 of 2.7 μM in HEK293T/PAD2 cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

480.53

Formula

C25H29FN6O3
CAS 号

2095109-82-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Aaron Muth, et al. Development of a Selective Inhibitor of Protein Arginine Deiminase 2. J Med Chem. 2017 Apr 13;60(7):3198-3211.

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