PROTAC BRD4 Degrader-2

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

PROTAC BRD4 Degrader-2 

PROTAC BRD4 Degrader-2 是由Cereblon配体和BRD4配体相连的PROTAC，对 BRD4 BD1 的 IC50 为 14.2 nM。

PROTAC BRD4 Degrader-2

PROTAC BRD4 Degrader-2 Chemical Structure

CAS No. : 2185795-53-1

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生物活性

PROTAC BRD4 Degrader-2 is a PROTAC connected by ligands for Cereblon and BRD4 with an IC50 of 14.2 nM against BRD4 BD1[1].

IC50 & Target[1]

BRD4 BD1

14.2 nM (IC50)

Cereblon

 

体外研究
(In Vitro)

PROTAC BRD4 Degrader-2 (Compound 17) inhibits the growth of THP-1 cell line with an IC50 of 1.83±0.016 μM[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: Human monocyte lymphoma cell line THP-1
Concentration: 72 hours
Incubation Time: 0.81-3.26 μM
Result: Showd high anti-proliferative potency.

分子量

757.79

Formula

C40H39N9O7
CAS 号

2185795-53-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Zhang F, et al. Discovery of a new class of PROTAC BRD4 degraders based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide. Bioorg Med Chem. 2020 Jan 1;28(1):115228.

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