RAF mutant-IN-1 | whatman (沃特曼)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

RAF mutant-IN-1

RAF mutant-IN-1 是RAF kinase 的抑制剂，信息来自专利WO2019107987A1，对C-RAF^340D/Y341D、B-RAF^V600E 和B-RAF^WT 的IC₅₀ 值分别为 21 nM、30 nM和392 nM。

RAF mutant-IN-1 Chemical Structure

CAS No. : 2340020-82-6

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生物活性

RAF mutant-IN-1 is a RAF kinase inhibitor, extracted from patent WO2019107987A1, with IC₅₀ values of 21 nM, 30 nM and 392 nM for C-RAF^340D/Y341D, B-RAF^V600E and B-RAF^WT, respectively^[1].

IC₅₀ & Target

C-RAF^340D/Y341D

21 nM (IC₅₀)

B-Raf^V600E

30 nM (IC₅₀)

BRAF^WT

392 nM (IC₅₀)

分子量

567.85

Formula

C₂₃H₁₈Cl₃FN₆O₂S

CAS 号

2340020-82-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. BAE, In Hwan, et al. Title of Invention: THIENO[3,2-d]PYRIMIDINE COMPOUND HA VING INHIBITORY ACTIVITY FOR PROTEIN KINASE. WO2019107987A1.

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