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Aniline-MPB-amino-C3-PBD
Aniline-MPB-amino-C3-PBD,是一种由吡咯苯二氮卓 (PBD) 组成的细胞毒性药物。Aniline-MPB-amino-C3-PBD 是一种序列选择性 DNA 小沟结合剂。Aniline-MPB-amino-C3-PBD 作为 ADC 的有效载荷。具有抗微生物活性。
Aniline-MPB-amino-C3-PBD Chemical Structure
CAS No. : 2412923-79-4
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生物活性 |
Aniline-MPB-amino-C3-PBD is a cytotoxic agent comprised non-alkylating group. Aniline-MPB-amino-C3-PBD is a sequence-selective DNA minor-groove binding agent. Aniline-MPB-amino-C3-PBD acts as the payload for ADCs. Antimicrobial activity[1]. |
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体外研究 (In Vitro) |
Aniline-MPB-amino-C3-PBD (compound 16) shows cytotoxicity with IC50s of 77, 72, 79, 184.3, 61.5, and 145.6 nM for SW48, LIM1215, SW620, U138-MG, A431, and REH cells, respectively. Aniline-MPB-amino-C3-PBD effectively stabilises DNA with a degree of sequence-specificity. Aniline-MPB-amino-C3-PBD possesses potent anti-bacterial effects against the gram negative strain E. coli K12 with potency of 2 pg/mL determined[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
758.86 |
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Formula |
C42H46N8O6 |
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CAS 号 |
2412923-79-4 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
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参考文献 |
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