上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
MBM-17S
MBM-17S 是有效的 NIMA-related kinase 2 (Nek2) 抑制剂,IC50 值为 3 nM,通过诱导细胞周期停滞和凋亡 (apoptosis),抑制癌细胞的增殖,具有抗肿瘤活性,且对小鼠没有明显的毒性。
MBM-17S Chemical Structure
CAS No. : 2083621-91-2
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生物活性 |
MBM-17S is a potent NIMA-related kinase 2 (Nek2) inhibitor, with an IC50 of 3 nM. MBM-17S effectively inhibits the proliferation of cancer cells by inducing cell cycle arrest and apoptosis. MBM-17S shows antitumor activities, and no obvious toxicity to mice[1]. |
IC50 & Target |
IC50: 3 nM (Nek2), 5800 nM (Aurora A)[1] |
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体外研究 (In Vitro) |
MBM-17S inhibits MGC-803, HCT-116, and Bel-7402 cells proliferation with IC50s of 0.48, 1.06, and 4.53 μM, respectively[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. Cell Cycle Analysis[1]
Apoptosis Analysis[1]
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体内研究 (In Vivo) |
MBM-17S (20 mg/kg; i.p.; twice a day for 21 days) exhibits good antitumor activity and a well-tolerated dose schedule[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
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分子量 |
716.74 |
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Formula |
C36H40N6O10 |
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CAS 号 |
2083621-91-2 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
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参考文献 |
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