RORγt agonist 1

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

RORγt agonist 1 

RORγt agonist 1 (compound 14) 是有效的，口服生物可利用的 RORγt 激动剂，EC50 为 20.8 nM。RORγt agonist 1 显示出高代谢稳定性，改善的水溶性和优异的小鼠 PK 特征。RORγt agonist 1 是用于癌症免疫疗法的 RORγt 激动剂的潜在候选物。

RORγt agonist 1

RORγt agonist 1 Chemical Structure

CAS No. : 2377378-89-5

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生物活性

RORγt agonist 1 (compound 14) is a potent, orally bioavailable RORγt agonist with an EC50 of 20.8 nM. RORγt agonist 1 showes high metabolic stability, improved aqueous solubility and excellent mouse PK profile. RORγt agonist 1 is a potential candidate of RORγt agonist for cancer immunotherapy[1].

IC50 & Target

EC50: 20.8 nM (RORγt)[1]
体内研究
(In Vivo)

RORγt agonist 1 shows high metabolic stability (t1/2 = 113 min) in mouse liver microsome and has improved aqueous solubility at pH 7.4[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

545.45

Formula

C24H17F6NO5S
CAS 号

2377378-89-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Zhu Y, et al. Discovery of aryl-substituted indole and indoline derivatives as RORγt agonists. Eur J Med Chem. 2019 Aug 6;182:111589.

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