Thalidomide-O-amido-PEG4-C2-NH2 hydrochloride

发表于由

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Thalidomide-O-amido-PEG4-C2-NH2 hydrochloride 

Thalidomide-O-amido-PEG4-C2-NH2 hydrochloride 是一种合成的 E3 连接酶配体-linker 偶联物，包含基于 Thalidomide 的 cereblon 配体和 1 个 linker。可用于合成 PROTAC 分子。

Thalidomide-O-amido-PEG4-C2-NH2 hydrochloride

Thalidomide-O-amido-PEG4-C2-NH2 hydrochloride Chemical Structure

CAS No. : 2245697-85-0

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生物活性

Thalidomide-O-amido-PEG4-C2-NH2 hydrochloride, a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs[1].

IC50 & Target

Cereblon

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

587.02

Formula

C25H35ClN4O10
CAS 号

2245697-85-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. James Bradner, et al. Methods to induce targeted protein degradation through bifunctional molecules. WO2016105518A1.

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