BCR-ABL-IN-3 | whatman (沃特曼)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

BCR-ABL-IN-3

BCR-ABL-IN-3 是一种有效且不可逆的 Bcr-Abl 抑制剂，对于 Ba/F₃Bcr-Abl^T3151 的 IC₅₀ 为 ≤100 nM。BCR-ABL-IN-3 具有抗癌活性。

BCR-ABL-IN-3 Chemical Structure

CAS No. : 2240191-12-0

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

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生物活性

BCR-ABL-IN-3 is a potent and irreversible Bcr-Abl inhibitor with an IC₅₀ of ≤100 nM for Ba/F₃Bcr-Abl^T3151. BCR-ABL-IN-3 has anti-cancer activity^[1].

IC₅₀ & Target^[1]

Ba/F₃Bcr-Abl^T3151

≤100 nM (IC₅₀)

体内研究
(In Vivo)

BCR-ABL-IN-3 (compound 7; 15 mg/kg; twice a day; for 19 days) has good antitumor effect in female NOD/SCID mice of 7-8 weeks weighing 21.8 g with Ba/F₃Bcr-Abl^T3151 cells^[1].
BCR-ABL-IN-3 (2 mg/kg for IV or 20mg/kg for PO) has a C_max of 5485 ng/mL and an AUC of 5450 h•ng/mL for IV in male Sprague Dawley rats of 7-8 weeks old weighing 210 g^[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

466.89

Formula

C₂₀H₁₇ClF₂N₄O₃S

CAS 号

2240191-12-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Hanyi Wang, et al. (hetero)arylamide compound for inhibiting protein kinase activity. WO2018133826A1.

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