Bleomycin A5 hydrochloride(Synonyms: Pingyangmycin hydrochloride)

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Bleomycin A5 hydrochloride (Synonyms: Pingyangmycin hydrochloride)

Bleomycin A5 (Pingyangmycin) hydrochloride 是一种抗肿瘤糖蛋白抗生素 (antibiotic)。Bleomycin A5 hydrochloride 抑制 Drp1 介导的线粒体分裂并诱导人鼻息肉源性成纤维细胞凋亡 (apoptosis)。Bleomycin A5 hydrochloride 的抗癌活性依赖于其产生 RNA 和 DNA 断裂的能力，从而导致细胞死亡

Bleomycin A5 hydrochloride(Synonyms: Pingyangmycin hydrochloride)

Bleomycin A5 hydrochloride Chemical Structure

CAS No. : 55658-47-4

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生物活性

Bleomycin A5 (Pingyangmycin) hydrochloride is an anti-neoplastic glycoprotein antibiotic. Bleomycin A5 suppresses Drp1-mediated mitochondrial fission and induces apoptosis in human nasal polyp-derived fibroblasts. Bleomycin A5 hydrochloride has anticancer activities relying on its ability to produce RNA and DNA breaks, thus, leading to cell death[1][2][3][4]..

分子量

1477.02

Formula

C57H90ClN19O21S2
CAS 号

55658-47-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Yang LC, et al. MEK inhibition enhances bleomycin A5-induced apoptosis in an oral cancer cell line: signaling mechanisms and therapeutic opportunities. J Oral Pathol Med. 2004;33(1):37-45.

    [2]. Wu F, et al. Bleomycin A5 suppresses Drp1 mediated mitochondrial fission and induces apoptosis in human nasal polyp derived fibroblasts. Int J Mol Med. 2021;47(1):346-360.

    [3]. Pan JB, et al. Rolipram attenuates bleomycin A5-induced pulmonary fibrosis in rats. Respirology. 2009;14(7):975-982.

    [4]. He Y, et al. Pingyangmycin and Bleomycin Share the Same Cytotoxicity Pathway. Molecules. 2016;21(7):862. Published 2016 Jun 30.

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