Duocarmycin A

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Duocarmycin A 

Duocarmycin A 是众所周知的抗肿瘤抗生素之一,是一种 DNA 烷基化剂,可有效地使 DNA 中富含 AT 的序列 3′ 末端的腺嘌呤 N3 烷基化。Duocarmycin A 作为一种化学研究剂,通常导致 HLC-2 细胞凋亡,包括染色质浓缩,DNA 直方图模式中的亚 G1 积累,以及procaspase-39 水平的降低。

Duocarmycin A

Duocarmycin A Chemical Structure

CAS No. : 118292-34-5

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生物活性

Duocarmycin A, which is one of well-known antitumor antibiotics, is a DNA alkylator and efficiently alkylates adenine N3 at the 3′ end of AT-rich sequences in the DNA. Duocarmycin A, as a chemotherapeutic agent, results HLC-2 cells typically apoptotic changes, including chromatin condensation, sub-G1 accumulation in DNA histogram pattern, and decrease in procaspase-3 and 9 levels[1].

IC50 & Target

Procaspase-3

 

Caspase-9

 

Duocarmycins

 

分子量

507.49

Formula

C26H25N3O8

CAS 号

118292-34-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Hirota M, et al. Distamycin A enhances the cytotoxicity of duocarmycin A and suppresses duocarmycin A-induced apoptosis in human lung carcinoma cells. Int J Biochem Cell Biol. 2007;39(5):988-96.

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