Imiquimod maleate(Synonyms: 马来酸咪喹莫特; R 837 maleate)

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Imiquimod maleate (Synonyms: 马来酸咪喹莫特; R 837 maleate)

Imiquimod maleate (R 837 maleate) 是一种 toll 样受体7 (TLR7) 激动剂，作为一种免疫反应修饰剂。Imiquimod maleate 在体内表现出抗病毒和抗肿瘤作用。Imiquimod maleate 可用于外生殖器、肛周疣、癌症和 COVID-19 的研究。

Imiquimod maleate(Synonyms: 马来酸咪喹莫特; R 837 maleate)

Imiquimod maleate Chemical Structure

CAS No. : 896106-16-4

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Imiquimod maleate 的其他形式现货产品:

Imiquimod Imiquimod hydrochloride

生物活性

Imiquimod maleate (R 837 maleate), an immune response modifier, is a selective toll like receptor 7 (TLR7) agonist. Imiquimod maleate exhibits antiviral and antitumor effects in vivo. Imiquimod maleate can be used for the research of external genital, perianal warts, cancer and COVID-19[1][2].

IC50 & Target[1][3]

TLR7

 

HSV-1

 

体内研究
(In Vivo)

In animal models, imiquimod stimulates the innate immune response by increasing NK cell activity, activating macrophages to secrete cytokines and nitric oxide, and inducing proliferation and differentiation of B lymphocytes. Imiquimod stimulates the innate immune response through induction, synthesis, and release of cytokines, including interferon-a (IFN-α), interleukin (IL)-6, and tumour necrosis factor (TNF)-α[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial

分子量

356.38

Formula

C18H20N4O4
CAS 号

896106-16-4
中文名称

马来酸咪喹莫特
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Athina Angelopoulou, et al. Imiquimod – A toll like receptor 7 agonist – Is an ideal option for management of COVID 19. Environ Res. 2020 Sep; 188: 109858.

    [2]. Aditya K Gupta, et al. Imiquimod: a review. J Cutan Med Surg. Nov-Dec 2002;6(6):554-60.

    [3]. Yuji Kan, et al. Imiquimod suppresses propagation of herpes simplex virus 1 by upregulation of cystatin A via the adenosine receptor A1 pathway. J Virol. 2012 Oct;86(19):10338-46.

    [4]. Michael P Schön, et al. The small antitumoral immune response modifier imiquimod interacts with adenosine receptor signaling in a TLR7- and TLR8-independent fashion. J Invest Dermatol. 2006 Jun;126(6):1338-47.

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