MC 1046(Synonyms: Impurity A of Calcipotriol)

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MC 1046 (Synonyms: Impurity A of Calcipotriol) 纯度: 91.48%

MC 1046(Impurity A of Calcipotriol)是钙泊三醇的杂质，钙泊三醇是1,25-Dihydroxyvitamin D3类似物。

MC 1046(Synonyms: Impurity A of Calcipotriol)

MC 1046 Chemical Structure

CAS No. : 126860-83-1

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1 mg ￥5000 In-stock
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MC 1046 相关产品

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生物活性

MC 1046(Impurity A of Calcipotriol) is an impurity of Calcipotriol; Calcipotriol (MC 903; Calcipotriene) is a ligand of VDR-like receptors. IC50 value: Target: Vitamin D3 analog that displays minimal effects on calcium homeostasis. Regulates cell differentiation and proliferation; Calcipotriol (MC 903; Calcipotriene) exhibits antiproliferative activity against human HL-60, HL60/MX2, MCF-7, T47D, SCC-25 and mouse WEHI-3 cancer cell lines.

分子量

410.59

Formula

C27H38O3
CAS 号

126860-83-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light, stored under nitrogen

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参考文献

  • [1]. Binderup (1993) Comparison of calcipotriol with selected metabolites and analogues of vitamin D3: effects on cell growth regulation in vitro and calcium metabolism in vivo. Pharmacol.Toxicol. 72 240.

    [2]. Knutson et al (1997) Pharmacokinetics and systemic effect on calcium homeostasis of 1a,24-dihydroxyvitamin D2 in rats. Biochem.Pharmacol. 53 829.

    [3]. Wietrzyk et al (2007) Antitumor properties of diastereomeric and geometric analogs of vitamin D3. Anticancer Drugs 18 447.111

    [4]. P.J. Marie, D. Connes, M. Hott, L. Miravet. Comparative effects of a novel Vitamin D Analogue MC-903 and 1,25-dihydroxyvitamin D3 on alkaline phosphatase activity, osteocalcin and DNA synthesis by human osteoblastic cells in culture. Bone. Volume 11, Issue 3, 1990, Pages 171-179

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