(Z)-SMI-4a

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

(Z)-SMI-4a 

(Z)-SMI-4a 是一种有效的，选择性的，细胞可渗透的且具有 ATP 竞争性的 Pim-1 抑制剂，其 IC50 为 24 μM，Ki 为 0.6 μM。(Z)-SMI-4a 还抑制 Pim-2 (IC50 为 100 μM)，并且不显着抑制其他丝氨酸/苏氨酸或酪氨酸激酶。(Z)-SMI-4a 具有抗癌活性。

(Z)-SMI-4a

(Z)-SMI-4a Chemical Structure

CAS No. : 438190-29-5

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生物活性

(Z)-SMI-4a is a poten, selective, cell-permeable and ATP-competitive Pim-1 inhibitor with an IC50 of 24 μM and a Ki of 0.6 µM. (Z)-SMI-4a also inhibits Pim-2 (IC50 of 100 μM), and does not significantly inhibit the other serine/threonine- or tyrosine-kinases. (Z)-SMI-4a has anticancer activity[1].

IC50 & Target[1]

PIM1

24 μM (IC50)

PIM1

0.6 μM (Ki)

PIM2

100 μM (IC50)

体外研究
(In Vitro)

(Z)-SMI-4a (0.5 µM; 1 hour; HEK-293T cells) treatment attenuates the autophosphorylation of tagged Pim-1 in intact cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: HEK-293T cells
Concentration: 0.5 µM
Incubation Time: 1 hour
Result: Caused a dose-dependent reduction in Pim-1-induced 4E-BP1 phosphorylation, with an IC50 of approximately 125 nM.

分子量

273.23

Formula

C11H6F3NO2S
CAS 号

438190-29-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Xia Z, et al. Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases. J Med Chem. 2009 Jan 8;52(1):74-86.

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