Demethylcantharidate disodium

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Demethylcantharidate disodium  纯度: ≥98.0%

Demethylcantharidate disodium 是一种内源性代谢产物，通过内质网应激诱导肝癌细胞凋亡。Demethylcantharidate disodium 对多种类型的癌症具有良好的抗癌活性。

Demethylcantharidate disodium

Demethylcantharidate disodium Chemical Structure

CAS No. : 129-67-9

规格 价格 是否有货 数量
10 mg ￥500 In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Demethylcantharidate disodium 相关产品

•相关化合物库:

  • Natural Product Library Plus
  • Clinical Compound Library Plus
  • Bioactive Compound Library Plus

生物活性

Demethylcantharidate disodium, an endogenous metabolite, induces apoptosis in hepatocellular carcinoma cells via ER stress. Demethylcantharidate disodium shows excellent anticancer activity against multiple types of cancer[1].

体外研究
(In Vitro)

Demethylcantharidate (0-100 μM; 0, 12, 24, 48 or 72 hours) disodium inhibits HCC cell proliferation[1].
Demethylcantharidate (0, 9, 18 or 36 µM; 24 hours) disodium dose dependently increases the levels of cleaved caspase-3, cleaved caspase-9, and Bax/Bcl-2[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: HCC cell lines (SMMC-7721 and Bel-7402)
Concentration: 0-100 μM
Incubation Time: 0, 12, 24, 48 or 72 hours
Result: Showed anti-proliferative activity in the two HCC cell lines.

Cell Viability Assay[1]

Cell Line: HCC cells
Concentration: 0, 9, 18 or 36 µM
Incubation Time: 24 hours
Result: Induced apoptosis in HCC cells via the intrinsic pathway.

体内研究
(In Vivo)

Demethylcantharidate disodium significantly decreases hepatocellular carcinoma tumorigenesis of SMMC-7721 cells in vivo[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial

分子量

230.13

Formula

C8H8Na2O5
CAS 号

129-67-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
溶解性数据
In Vitro: 

DMSO : < 1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble or slightly soluble)
参考文献

  • [1]. Ye M, et al. Sodium demethylcantharidate induces apoptosis in hepatocellular carcinoma cells via ER stress. Am J Transl Res. 2019;11(5):3150-3158. Published 2019 May 15.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务