Boc-piperazine-benzoic acid

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Boc-piperazine-benzoic acid 

Boc-piperazine-benzoic acid 是一种 PROTAC linker,可用来合成 PROTAC,例如雄激素受体 (AR) 降解剂 ARD-2128 (HY-13229)。

Boc-piperazine-benzoic acid

Boc-piperazine-benzoic acid Chemical Structure

CAS No. : 162046-66-4

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500 mg ¥400 In-stock
1 g ¥640 In-stock
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生物活性

Boc-piperazine-benzoic acid is a PROTAC linker and can be used in the synthesis of PROTACs, such as PROTAC androgen receptor (AR) degrader ARD-2128 (HY-13229)[1].

体外研究
(In Vitro)

ARD-2128 is a highly potent, orally bioavailable PROTAC androgen receptor (AR) degrader. ARD-2128 effectively reduces AR protein, suppresses AR-regulated genes in tumor tissues, and inhibits growth of tumor without signs of toxicity. ARD-2128 has the potential for the research of the prostate cancer[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

306.36

Formula

C16H22N2O4

CAS 号

162046-66-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献
  • [1]. Han X, et al. Strategies toward Discovery of Potent and Orally Bioavailable Proteolysis Targeting Chimera Degraders of Androgen Receptor for the Treatment of Prostate Cancer. J Med Chem. 2021;64(17):12831-12854.

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