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Acolbifene hydrochloride (Synonyms: EM-652 hydrochloride; SCH 57068 hydrochloride) 纯度: 98.48%
Acolbifene (EM-652) hydrochloride 是 EM800 的活性代谢产物,是一种口服活性的选择性雌激素受体调节剂 (SERM)。Acolbifene (EM-652) hydrochloride 抑制雌二醇诱导的 ERα (IC50 = 2 nM) 和 ERβ (IC50 = 0.4 nM) 转录活性。Acolbifene (EM-652) hydrochloride 对乳腺和子宫有明显的抗雌激素作用。Acolbifene (EM-652) hydrochloride 具有抗癌活性。
Acolbifene hydrochloride Chemical Structure
CAS No. : 252555-01-4
规格 | 价格 | 是否有货 | 数量 |
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10 mM * 1 mL in DMSO | ¥2170 | In-stock | |
5 mg | ¥2000 | In-stock | |
10 mg | ¥3500 | In-stock | |
25 mg | ¥6500 | In-stock | |
50 mg | ¥9500 | In-stock | |
100 mg | ¥13500 | In-stock | |
200 mg | 询价 | ||
500 mg | 询价 |
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Acolbifene hydrochloride 相关产品
•相关化合物库:
- Drug Repurposing Compound Library Plus
- Clinical Compound Library Plus
- Bioactive Compound Library Plus
- Anti-Cancer Compound Library
- Clinical Compound Library
- Drug Repurposing Compound Library
- Orally Active Compound Library
- Anti-Breast Cancer Compound Library
生物活性 |
Acolbifene (EM-652) hydrochloride, an active metabolite of EM800, is an orally active, cancer-preventing selective estrogen receptor modulator (SERM). Acolbifene (EM-652) hydrochloride inhibits estradiol (E2)-induced transcriptional activity of ERα (IC50=2 nM) and ERβ (IC50=0.4 nM). Acolbifene (EM-652) hydrochloride exerts a potent and pure antiestrogenic action in the mammary gland and uterus. Anticarcinogenic properties[1][2][3][4][5]. |
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IC50 & Target[5] |
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体外研究 (In Vitro) |
Acolbifene (ACOL) does not affect pathways of cholesterol synthesis, supporting the involvement of the clearance-related receptors in its hypocholesterolemic action[2]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
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体内研究 (In Vivo) |
Acolbifene (ACOL) reduces food intake and strongly decreases cholesterolemia in rats fed a cholesterol-free diet[2]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
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Clinical Trial |
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分子量 |
494.02 |
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Formula |
C29H32ClNO4 |
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CAS 号 |
252555-01-4 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
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溶解性数据 |
In Vitro:
DMSO : 180 mg/mL (364.36 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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