Paeoniflorigenone(Synonyms: 芍药甙元酮)

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Paeoniflorigenone (Synonyms: 芍药甙元酮) 纯度: ≥98.0%

Paeoniflorigenone 是从牡丹皮中提取的一种有效成分，具有选择性诱导肿瘤细胞凋亡 (apoptosis) 和抗增殖作用。

Paeoniflorigenone(Synonyms: 芍药甙元酮)

Paeoniflorigenone Chemical Structure

CAS No. : 80454-42-8

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生物活性

Paeoniflorigenone, isolated as an active ingredient from the root of moutan cortex, induces apoptosis selectively in the cancer cell lines and exhibits antiproliferative effect[1].

体外研究
(In Vitro)

Paeoniflorigenone (0-30 μM; 0-72 hours) significantly decreases the cell proliferation of tumor cell lines and inhibits the proliferation of normal cell lines[1].
Paeoniflorigenone (0-30 μM; 24-72 hours) significantly induces apoptotic DNA fragmentation selectively in tumor cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: TIG-1, 3T3-L1, HL60, Jurkat and HeLa cells
Concentration: 0-30 μM
Incubation Time: 0-72 hours
Result: Significantly decreased the cell proliferation of tumor cell lines and inhibited the proliferation of normal cell lines.

Apoptosis Analysis[1]

Cell Line: TIG-1 and 3T3-L1 (normal cells), HL60, Jurkat, and HeLa cells (tumor cells)
Concentration: 0, 1, 3, 10, 30 μM
Incubation Time: 24 and 72 hours
Result: Induced DNA fragmentation in three tumor cell lines, but not in two normal cell lines.

分子量

318.32

Formula

C17H18O6
CAS 号

80454-42-8
中文名称

芍药甙元酮；芍药苷元酮
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
参考文献

  • [1]. Huang Y, et al. Apoptosis-inducing activity and antiproliferative effect of Paeoniflorigenone from moutan cortex. Biosci Biotechnol Biochem. 2017;81(6):1106-1113.

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