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Diazepinomicin (Synonyms: ECO-4601; TLN-4601; BU 4664L)
Diazepinomicin (TLN-4601) 是Micromonospora sp 的次生代谢产物，可抑制EGF 诱导的 Ras-ERK MAPK 信号通路，可诱导凋亡。是一种可用于 K-Ras 突变型的抗肿瘤药物。
Diazepinomicin Chemical Structure
CAS No. : 733035-26-2
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| 100 mg | 询价 | ||
| 250 mg | 询价 | ||
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| 生物活性 |
Diazepinomicin (TLN-4601) is a secondary metabolite produced by Micromonospora sp. Diazepinomicin (TLN-4601) inhibits the EGF-induced Ras-ERK MAPK signaling pathway and induces apoptosis. An anti-tumor agent for K-Ras mutant models[1]. |
IC50 & Target |
Diazepinomicin (TLN-4601) inhibits the EGF-induced Ras-ERK MAPK signaling pathway post Ras prenylation and prior to MEK activation[1]. |
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| 分子量 |
462.58 |
| Formula |
C28H34N2O4 |
| CAS 号 |
733035-26-2 |
| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
| 储存方式 |
-20°C, protect from light, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen) |
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