Gossypin

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Gossypin 

Gossypin 是从 Hibiscus vitifolius 中分离得到的一种黄酮，具有抗氧化、抗炎、抗癌、抗衰老、抗糖尿病和保护肝脏的活性。Gossypin 抑制 NF-κB 和 NF-κB 的调节基因表达。在小鼠原代骨髓细胞和 RAW264.7 细胞中，Gossypin 也可抑制 RANKL 诱导的破骨细胞形成。

Gossypin

Gossypin Chemical Structure

CAS No. : 652-78-8

规格 价格 是否有货
5 mg ￥2200 询问价格 & 货期
10 mg ￥3750 询问价格 & 货期

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生物活性

Gossypin is a flavone isolated from Hibiscus vitifolius and has antioxidant, antiinflammatory, anticancer, anticataract, antidiabetic, and hepatoprotective activities. Gossypin inhibits NF-κB and NF-κB-regulated gene expression. Gossypin inhibits RANKL-induced osteoclastogenesis both in mouse primary bone marrow cells and RAW 264.7 cells in vitro[1][2].

IC50 & Target

IC50: NF-κB[1]
分子量

480.38

Formula

C21H20O13
CAS 号

652-78-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Ajaikumar B Kunnumakkara, et al.  Gossypin, a pentahydroxy glucosyl flavone, inhibits the transforming growth factor beta-activated kinase-1-mediated NF-kappaB activation pathway, leading to potentiation of apoptosis, suppression of invasion, and abrogation of osteoclastogenesis. Blood. 2007 Jun 15;109(12):5112-21.

    [2]. Kanika Patel, et al. Gossypin: A phytochemical of multispectrum potential. the Journal of Coastal Life Medicine.

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