R18(Synonyms: PHCVPRDLSWLDLEANMCLP)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

R18 (Synonyms: PHCVPRDLSWLDLEANMCLP)

R18 是 14-3-3 的肽拮抗剂，其 K_D 值为 70-90 nM。R18 可有效阻断 14-3-3 与其配体 Raf-1激酶的结合，可有效地消除 14-3-3 对磷酸酶诱导的 Raf-1 失活的保护作用。

R18 Chemical Structure

CAS No. : 211364-78-2

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R18 的其他形式现货产品:

R18 TFA

生物活性	R18 is a peptide antagonists of 14-3-3, with a K_D of 70-90 nM. R18 efficiently blocks the binding of 14-3-3 to the kinase Raf-1, a physiological ligand of 14-3-3, and effectively abolished the protective role of 14-3-3 against phosphatase-induced inactivation of Raf-1^[1].
分子量	2309.69
Formula	C₁₀₁H₁₅₇N₂₇O₂₉S₃
CAS 号	211364-78-2
Sequence	Pro-His-Cys-Val-Pro-Arg-Asp-Leu-Ser-Trp-Leu-Asp-Leu-Glu-Ala-Asn-Met-Cys-Leu-Pro
Sequence Shortening	PHCVPRDLSWLDLEANMCLP
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. B Wang, et al. Isolation of high-affinity peptide antagonists of 14-3-3 proteins by phage display. Biochemistry. 1999 Sep 21;38(38):12499-504.

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