Azido-PEG5-triethoxysilane

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Azido-PEG5-triethoxysilane  纯度: ≥98.0%

Azido-PEG5-triethoxysilane 是一种 PROTAC linker，属于 PEG 类。可用于合成 PROTAC 分子。

Azido-PEG5-triethoxysilane

Azido-PEG5-triethoxysilane Chemical Structure

规格 价格 是否有货 数量
100 mg ￥6500 In-stock
200 mg   询价  
500 mg   询价  

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生物活性

Azido-PEG5-triethoxysilane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

538.71

Formula

C22H46N4O9Si
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Pure form -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 250 mg/mL (464.07 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.8563 mL 9.2814 mL 18.5629 mL
5 mM 0.3713 mL 1.8563 mL 3.7126 mL
10 mM 0.1856 mL 0.9281 mL 1.8563 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

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