Bis-PEG6-NHS ester

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Bis-PEG6-NHS ester  纯度: ≥97.0%

Bis-PEG6-NHS ester 是一种 PROTAC 连接桥，属于 PEG 类。Bis-PEG6-NHS ester 可用于合成一系列 PROTAC 分子。Bis-PEG6-NHS ester 是一种可降解 (cleavable) 的 ADC 连接桥，用于抗体药物结合物 (ADCs) 的合成。

Bis-PEG6-NHS ester

Bis-PEG6-NHS ester Chemical Structure

CAS No. : 1526718-98-8

规格 价格 是否有货 数量
100 mg ￥2300 In-stock
250 mg ￥4000 In-stock
500 mg   询价  
1 g   询价  

* Please select Quantity before adding items.

生物活性

Bis-PEG6-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG6-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC50 & Target[1]

Cleavable

 

PEGs

 

Alkyl/ether

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

576.55

Formula

C24H36N2O14
CAS 号

1526718-98-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture

*该产品在溶液状态不稳定，建议您现用现配，即刻使用。
溶解性数据
In Vitro: 

DMSO : 125 mg/mL (216.81 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.7345 mL 8.6723 mL 17.3445 mL
5 mM 0.3469 mL 1.7345 mL 3.4689 mL
10 mM 0.1734 mL 0.8672 mL 1.7345 mL

*

请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液；该产品在溶液状态不稳定，建议您现用现配，即刻使用。
参考文献

  • [1]. John L. Magna, et al. Highly potent multimeric e-selectin antagonists. WO2018068010A1.

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