Fmoc-NH-PEG3-CH2CH2COOH

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Fmoc-NH-PEG3-CH2CH2COOH  纯度: 99.80%

Fmoc-NH-PEG3-CH2CH2COOH 是一种可降解的 ADC linker，用于抗体药物偶联物 (ADC) 合成。Fmoc-NH-PEG3-CH2CH2COOH 也是一种基于 PEG 的 PROTAC linker，可用于 PROTAC 的合成。

Fmoc-NH-PEG3-CH2CH2COOH

Fmoc-NH-PEG3-CH2CH2COOH Chemical Structure

CAS No. : 867062-95-1

规格 价格 是否有货 数量
50 mg ￥1000 In-stock
100 mg ￥1700 In-stock
200 mg   询价  
500 mg   询价  

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生物活性

Fmoc-NH-PEG3-CH2CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-NH-PEG3-CH2CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

Cleavable

 

PEGs

 

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

443.49

Formula

C24H29NO7
CAS 号

867062-95-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献

  • [1]. Kyoji TSUCHIKAMA, et al. Linkers for antibody drug conjugates. WO2018218004A1.

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