TC-Mps1-12

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

TC-Mps1-12  纯度: ≥99.0%

TC-Mps1-12 是一种高效、选择性的 Mps1 抑制剂，其 IC50 值为 6.4 nM。

TC-Mps1-12

TC-Mps1-12 Chemical Structure

CAS No. : 1206170-62-8

规格 价格 是否有货 数量
1 mg ￥1750 In-stock
5 mg ￥5200 In-stock
10 mg ￥8800 In-stock
50 mg   询价  
100 mg   询价  

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生物活性

TC-Mps1-12 is a potent and selective monopolar spindle 1 (Mps1) inhibitor, with an IC50 of 6.4 nM[1].

IC50 & Target

IC50: 6.4 nM (Mps1)[1]
体外研究
(In Vitro)

TC-Mps1-12 inhibits the growth of pMps1 cell lines with IC50 values of 131 nM in autophosphorylation assay[1].
TC-Mps1-12 (72 hours) inhibits the growth of cells in a dose-dependent manner and with an IC50 values of 0.84 μM[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: 549 cells
Concentration:
Incubation Time: 72 hours
Result: Inhibited the growth of cells in a dose-dependent manner and with an IC50 values of 0.84 μM.

体内研究
(In Vivo)

TC-Mps1-12 (25-100 mg/kg; p.o.; daily; for 19 days) inhibits the growth of A549 cells in a dose-dependent manner in vivo. At a dose of 100 mg/kg, TC-Mps1-12 exhibits 47% tumor growth inhibition without body weight loss[1].
TC-Mps1-12 shows good PK properties with a Cmax of 3542 ng/mL and AUC of 6604 ng h/mL at an oral dose of 25 mg/kg[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: A549 mouse xenograft model[1]
Dosage: 25 mg/kg, 50 mg/kg, 100 mg/kg
Administration: Oral administration; once daily; for 19 days
Result: Inhibited the growth of A549 cells in a dose-dependent manner.
Animal Model: A549 mouse xenograft model (pharmacokinetic )[1]
Dosage: 25 mg/kg
Administration: Oral administration
Result: Cmax = 3542 ng/mL, AUC = 6604 ng h/mL

分子量

324.38

Formula

C17H20N6O
CAS 号

1206170-62-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献

  • [1]. Kusakabe K, et al. Diaminopyridine-based potent and selective mps1 kinase inhibitors binding to an unusual flipped-Peptide conformation. ACS Med Chem Lett. 2012 Jun 6;3(7):560-4.

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