Leelamine hydrochloride(Synonyms: 脱氢松香胺盐酸盐)

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Leelamine hydrochloride (Synonyms: 脱氢松香胺盐酸盐)

Leelamine hydrochloride 是一种从松树皮中提取的三环二萜分子。Leelamine hydrochloride 是一种大麻素 1 型 (CB1) 激动剂，也是前列腺癌细胞中 SREBP1 调节的脂肪酸/脂质合成的抑制剂，不受雄激素受体状态的影响。Leelamine hydrochloride 抑制调节脂肪酸合成的雄激素受体 (androgen receptor) 的转录活性。

Leelamine hydrochloride(Synonyms: 脱氢松香胺盐酸盐)

Leelamine hydrochloride Chemical Structure

CAS No. : 16496-99-4

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生物活性

Leelamine hydrochloride is a tricyclic diterpene molecule that is extracted from the bark of pine trees[1]. Leelamine hydrochloride is a cannabinoid receptor type 1 (CB1) agonist and a inhibitor of SREBP1-regulated fatty acid/lipid synthesis in prostate cancer cells that is not affected by androgen receptor status. Leelamine hydrochloride suppresses transcriptional activity of androgen receptor, which is known to regulate fatty acid synthesis[2,3].

IC50 & Target[2]

CB1

 

分子量

321.93

Formula

C20H32ClN
CAS 号

16496-99-4
中文名称

脱氢松香胺盐酸盐
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Kuzu OF, et al. Leelamine mediates cancer cell death through inhibition of intracellular cholesterol transport. Mol Cancer Ther. 2014 Jul;13(7):1690-703.

    [2]. A.O. Ibegbu, et al. Therapeutic Potentials and uses of Cannabinoid Agonists in Health and Disease Conditions. British Journal of Pharmacology and Toxicology 3(2): 76-88, 2012

    [3]. Singh KB, et al. Leelamine is a Novel Lipogenesis Inhibitor in Prostate Cancer Cells In Vitro and In Vivo. Mol Cancer Ther. 2019 Aug 8.

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