UCN-02(Synonyms: 7-epi-Hydroxystaurosporine)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

UCN-02 (Synonyms: 7-epi-Hydroxystaurosporine)

UCN-02 (7-epi-Hydroxystaurosporine) 是一种由链霉菌属 N-126 菌株产生的，选择性的蛋白激酶 C (PKC) 抑制剂，对 PKC 和 PKA 作用的 IC50 值分别为 62 nM 和 250 nM。 UCN-02 对 HeLa S3 细胞具有细胞毒性，能抑制其生长。

UCN-02(Synonyms: 7-epi-Hydroxystaurosporine)

UCN-02 Chemical Structure

CAS No. : 121569-61-7

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

UCN-02 (7-epi-Hydroxystaurosporine) is a selective protein kinase C (PKC) inhibitor produced by Streptomyces strain N-12, with IC50s of 62 nM and 250 nM for PKC and protein kinase A (PKA), respectively. UCN-02 (7-epi-Hydroxystaurosporine) displays cytotoxic effect on the growth of HeLa S3 cells[1][2].

IC50 & Target

IC50: 62 nM (PKC), 250 nM (PKA)[2]
分子量

482.53

Formula

C28H26N4O4
CAS 号

121569-61-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Pure form -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
参考文献

  • [1]. Takahashi I, et al. UCN-01 and UCN-02, new selective inhibitors of protein kinase C. I. Screening, producing organism and fermentation. J Antibiot (Tokyo). 1989 Apr;42(4):564-70.

    [2]. Takahashi I, et al. UCN-01 and UCN-02, new selective inhibitors of protein kinase C. II. Purification, physico-chemical properties, structural determination and biological activities. J Antibiot (Tokyo). 1989 Apr;42(4):571-6.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务