Aspirin-d4(Synonyms: Acetylsalicylic Acid-d4; ASA-d4)

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Aspirin-d4 (Synonyms: Acetylsalicylic Acid-d4; ASA-d4) 纯度: 98.85%

Aspirin-d4 (Acetylsalicylic Acid-d4) 是 Aspirin 的氘代物。Aspirin是非选择性和不可逆的 COX-1 和 COX-2 抑制剂，IC50 分别为5，210 μg/mL。

Aspirin-d4(Synonyms: Acetylsalicylic Acid-d4; ASA-d4)

Aspirin-d4 Chemical Structure

CAS No. : 97781-16-3

规格 价格 是否有货 数量
1 mg ￥1900 In-stock
5 mg ￥6500 In-stock
10 mg   询价  
50 mg   询价  

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生物活性

Aspirin-d4 (Acetylsalicylic Acid-d4) is the deuterium labeled Aspirin. Aspirin is a non-selective and irreversible inhibitor of COX-1 and COX-2 with IC50s of 5 and 210 μg/mL[1][2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

184.18

Formula

C9H4D4O4
CAS 号

97781-16-3
中文名称

阿司匹林 d4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Mitchell JA, et al. Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and induciblecyclooxygenase. Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11693-7.

    [3]. Vane JR, et al. The mechanism of action of aspirin. Thromb Res. 2003 Jun 15;110(5-6):255-8.

    [4]. Wu KK, et al. Aspirin and other cyclooxygenase inhibitors: new therapeutic insights. Semin Vasc Med. 2003 May;3(2):107-12.

    [5]. Kopp E, et al. Inhibition of NF-kappa B by sodium salicylate and aspirin. Science. 1994 Aug 12;265(5174):956-9.

    [6]. Blanco FJ, et al. Effect of antiinflammatory drugs on COX-1 and COX-2 activity in human articular chondrocytes. J Rheumatol. 1999 Jun;26(6):1366-73.

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