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HMN-154 纯度: 97.18%
HMN-154是一种新型的苯磺酰胺类抗癌化合物。HMN-154与NF-YB相互作用,从而中断NF-Y异源三聚体与DNA的结合。
HMN-154 Chemical Structure
CAS No. : 173528-92-2
规格 | 价格 | 是否有货 | 数量 |
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10 mM * 1 mL in DMSO | ¥2338 | In-stock | |
5 mg | ¥2900 | In-stock | |
10 mg | ¥4400 | In-stock | |
25 mg | ¥6500 | In-stock | |
50 mg | ¥8000 | In-stock | |
100 mg | ¥9500 | In-stock | |
200 mg | 询价 | ||
500 mg | 询价 |
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HMN-154 相关产品
•相关化合物库:
- Natural Product Like Compound Library
- Natural Product Like Compound Library
- Bioactive Compound Library Plus
- Anti-Cancer Compound Library
生物活性 |
HMN-154 is a novel benzenesulfonamide anticancer compound; inhibits KB and colon38 cells with IC50 values of 0.0026 and 0.003 μg/mL, respectively. |
IC50 & Target |
IC50: 0.0026 μg/mL (KB cells), 0.003 μg/mL (colon38 cells)[1] |
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体外研究 (In Vitro) |
HMN-154 interacts with NF-YB and thereby interrupts the binding of the NF-Y heterotrimer to DNA. NF-YB and thymosin β-10 are specific cellular binding proteins of HMN-154 and that this shared region is necessary for the binding to HMN-154. HMN-154 inhibits DNA binding of NF-Y to the human major histocompatibility complex class II human leukocyte antigen DRA Y-box sequence in a dose-dependent manner. HMN-154 shows very strong cytotoxicity against KB and colon38 cells with an IC50 value of 0.0026 and 0.003 μg/mL, respectively. HMN-154/BSA binds recombinant NF-YB or thymosin β-10 and the binding is inhibited by the addition of HMN-154 as the competitor. The binding between HMN-154 and NF-YB is specific and depends on its cytotoxicity[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
366.43 |
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Formula |
C20H18N2O3S |
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CAS 号 |
173528-92-2 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO : ≥ 15 mg/mL (40.94 mM) * “≥” means soluble, but saturation unknown. 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
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参考文献 |
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Cell Assay [1] |
Cells are seeded into a 96-well microplate at a cell density of 10000/well. Drug is added on the next day, and the plate then is incubated for 72 h at 37°C. The growth inhibitory concentration is measured by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
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参考文献 |
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