(R)-(-)-Ibuprofen-d3(Synonyms: (R)-Ibuprofen-d3)

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(R)-(-)-Ibuprofen-d3 (Synonyms: (R)-Ibuprofen-d3)

(R)-(-)-Ibuprofen-d3 ((R)-Ibuprofen-d3) 是 (R)-(-)-Ibuprofen 的氘代物。(R)-(-)-Ibuprofen 是 Ibuprofen 的 R 型异构体，对 COX 无作用，可以抑制 NF-κB 的活化；(R)-(-)-Ibuprofen 具有抗炎作用，可用于缓解疼痛的研究。

(R)-(-)-Ibuprofen-d3(Synonyms: (R)-Ibuprofen-d3)

(R)-(-)-Ibuprofen-d3 Chemical Structure

CAS No. : 121702-86-1

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生物活性

(R)-(-)-Ibuprofen-d3 ((R)-Ibuprofen-d3) is the deuterium labeled (R)-(-)-Ibuprofen. (R)-(-)-Ibuprofen is the R enantiomer of Ibuprofen, inactive on COX, inhibits NF-κB activation; (R)-(-)-Ibuprofen exhibits anti-inflammatory and antinociceptive effects.

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

209.30

Formula

C13H15D3O2
CAS 号

121702-86-1
中文名称

(R)-(-)-布洛芬 d3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Evans AM, et al. Comparative pharmacology of S(+)-ibuprofen and (RS)-ibuprofen. Clin Rheumatol. 2001 Nov;20 Suppl 1:S9-14.

    [3]. Scheuren N, et al. Modulation of transcription factor NF-kappaB by enantiomers of the nonsteroidal drug ibuprofen. Br J Pharmacol. 1998 Feb;123(4):645-52.

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